
Isaac Mann was born in Virginia on March 24, 1791. He served as a Private in Captain John Williams Company of the Ohio Militia during the War of 1812. This company was the first to be stationed at Fort Loramie during the War of 1812.
His first wife, Mary Ann Ludlow, died in 1812. They had one daughter named Lucinda. In 1813, he married Abigail "Catherine" Williams, daughter of John and Elizabeth Tawney Williams. Family tradition states that he was well educated, having attended college until the age of twenty-one. Isaac owned and operated the first sawmill in Shelby County. The sawmill was located in Ft. Loramie, Ohio.
Isaac and his family lived in Oran, Ohio. The present day crossroads in this village are located near the center of his farm.

In 1852, Isaac deeded land and donated materials for the community church and cemetery. He also demonstrated his benevolence by serving as the Cynthian Township Overseer of the Poor.
In his latter years, the Sidney Journal notes the advent of spring being enjoyed by Isaac Mann, "the nature lover".
Most of Isaac's children moved west and settled on land that his father, Colonel John Mann, purchased in Indiana. Isaac received a military land grant in Darke County, Ohio for his service in the War of 1812. At his death the land passed to his son Lewis Jackson Mann, who stayed in this area to care for his aging mother.

Isaac died in 1860, and was survived by his wife and ten children.
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